Protective effects of melatonin on lung damage associated with one-lung ventilation: An experimental study
نویسندگان
چکیده
منابع مشابه
One-lung ventilation induces hyperperfusion and alveolar damage in the ventilated lung: an experimental study.
BACKGROUND One-lung ventilation (OLV) increases mechanical stress in the lung and affects ventilation and perfusion (V, Q). There are no data on the effects of OLV on postoperative V/Q matching. Thus, this controlled study evaluates the influence of OLV on V/Q distribution in a pig model using a gamma camera technique [single-photon emission computed tomography (SPECT)] and relates these findin...
متن کاملProtective strategies for one-lung ventilation
provided the original work is properly cited. CC Hypoxemia and acute lung injury (ALI) are major concerns with one-lung ventilation (OLV) during thoracic surgery. Hypoxemia is usually the result of alveolar hypoventilation and an increasing shunt fraction, whereas ALI is caused by ventilatory stress (volutrauma, atelectrauma, and barotrauma), reexpansion pulmonary injury, and the lung surgery i...
متن کاملIndependent Lung Ventilation and One Lung Ventilation
The application of the independent lung ventilation (ILV) in adults has been described by Carlon and co-workers in 1978 and subsequently by other investigators. In 1983 Hedenstierna and coworkers using a bilumen tube suitable for prolonged intubation, and two Servo Ventilator 900 B (Siemens) adapted for synchronization, treated a wide range of clinical conditions. Following this experience, the...
متن کاملEffects of lung protective mechanical ventilation associated with permissive respiratory acidosis on regional extra-pulmonary blood flow in experimental ARDS
BACKGROUND Lung protective mechanical ventilation with limited peak inspiratory pressure has been shown to affect cardiac output in patients with ARDS. However, little is known about the impact of lung protective mechanical ventilation on regional perfusion, especially when associated with moderate permissive respiratory acidosis. We hypothesized that lung protective mechanical ventilation with...
متن کاملAn Animal Model for the Study of Lung Protective Therapies During One Lung Ventilation (OLV) in Children
One-lung ventilation (OLV) is the intentional collapse of one lung during surgical procedures in the chest. The objective of this report is to demonstrate that a piglet model of pediatric OLV mimics the clinical sequelae, and thus is valid to study lung protective interventions. Pediatric pigs (n = 7; 21 ± 1 d old; 7.7 ± 0.5 kg) were instrumented and exposed to OLV (left lung collapsed) for 3 h...
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ژورنال
عنوان ژورنال: The Turkish Journal of Thoracic and Cardiovascular Surgery
سال: 2020
ISSN: 1301-5680,2149-8156
DOI: 10.5606/tgkdc.dergisi.2020.18261